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Following oral administration, 2% to 4% of the unchanged diltiazem appears in the urine. National Library of Medicine Symptomatic hypotension occurred in 3.2% of patients. Bethesda, MD 20894, Web Policies Overdosage experience is limited. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. PDF Memorial Medical Center Intravenous Medication Use Guidelines At the first sign of extravasation, the following steps are recommended: (1) stop administration of IV fluids immediately, (2) disconnect the IV tube from the cannula, (3) aspirate any residual drug from the cannula, (4) administer a drug-specific antidote, and (5) notify the physician (Fig. Use within 24 hours. endstream endobj startxref Management of extravasation includes nursing intervention and thermal application. Therapists will always feel nervous during the medical team-patient communication because of guilt. MeSH Do not take extra medicine to make up the missed dose. Available from: Le A, Patel S. Extravasation of noncytotoxic drugs: a review of the literature. 125 mg per 25 mL (5 mg/mL) The chemical structure is: Diltiazem hydrochloride, USP is a white crystalline powder with a bitter taste. For continued reduction of the heart rate (up to 24 hours) in patients with atrial fibrillation or atrial flutter, an intravenous infusion of diltiazem hydrochloride injection may be administered. Supplement 1. Keywords: } !1AQa"q2#BR$3br 50 mg per 10 mL (5 mg/mL) Documentation procedure may differ between treatment centers (documentation form); however, certain items are mandatory for patient safety and legal purposes: (1) patient name and number, (2) date and time of the extravasation, (3) name of the drug extravasated and the diluent used (if applicable), (4) signs and symptoms (also reported by the patient), (5) description of the IV access, (6) extravasation area (and the approximate amount of the drug extravasated), and (7) management steps with time and date. Gastrointestinal: Constipation, elevated SGOT or alkaline phosphatase, nausea, vomiting 2.5-3.6 Extravasation: may cause tissue damage Do not flush Albumin 4.5% Infusion Normal blood volume: 1-2ml/min Hypovolaemia or shock: up to 1 L/hour Plasma exchange: up to Dermatologic events progressing to erythema multiforme and/or exfoliative dermatitis have been infrequently reported following oral diltiazem. 50 mg per 10 mL For Direct Intravenous Bolus Injection and 5. HCl Injection Diltiazem HCl Injection Based on the results of pharmacokinetic studies in healthy volunteers administered different oral diltiazem hydrochloride formulations, constant rate intravenous infusions of diltiazem hydrochloride at 3, 5, 7, and 11 mg/h are predicted to produce steady-state plasma diltiazem concentrations equivalent to 120-, 180-, 240-, and 360-mg total daily oral doses of diltiazem hydrochloride tablets or diltiazem hydrochloride extended-release capsules. 125 mg per 25 mL Patients should be dosed on an individual basis and reference should be made to the respective manufacturer's package insert for information relative to dosage and administration. Heart rate reduction may last from 1 to 3 hours. Mayo Clinic does not endorse companies or products.