Papillary Thyroid Cancer: the most common type of thyroid cancer. Afirma GSC (NOT GEC) 50% Suspicious Fayadosky Oct 30, 2018 10:56 AM (edited Nov 04) Results came back 50% Suspicious for FN (Follicular Neoplasm) with positive HRAS c.18HRAS c.182A>G (Q61R) Negative for BRAF, RET/ptc1 and ptc3 Any Insights? The Afirma GSC is designed to help clinicians manage these patients. Thyroid Nodules: https://www.thyroid.org/thyroid-nodules/. Indeterminate means the pathologist cannot tell if the nodule is benign or malignant with certainty. Careers. In May 2013 I spoke to Barbara Rath Smith the executive director of The American Thyroid Association and she said she was going to email articles as files to download and she did. The positive predictive value of the GSC is 47.1%.1 Results Afirma GSC results may help guide surgical decision making in patients with thyroid nodules. So much good info but I wish I had read this before I had agreed with my endo on his prescription for rai:( In fact, i am currently on my fifth day of my 7-10 day rai staycation. Patients usually return home or to work after the biopsy without any ill effects. I heard about the Afirma analysis , spent $5000 on the test and the results are even more confusing !! Hello. Seeking a second opinion I went to a leading hospital. I don't understand the results , I thought that if the result is Benign it means you have no cancer genes and it is 95% sure you won't get cancer . The Afirma Genomic Sequencing Classifier (GSC) is used to rule out malignancy and reclassify cytologically indeterminate (Bethesda III or IV) nodules to molecularly benign or suspicious ( 5 ). WHAT ARE THE IMPLICATIONS OF THIS STUDY? This approach is being marked by several laborartories and was reviewed in the December 2011 issue of Clinical Thyroidology. I was told to monitor my nodules every couple years using ultra-sound and if they increased in size, they needed to have FNA done. Follicular and hurthle cells are normal cells found in the thyroid. I had my surgery in NYC, it took 2 hours, and I went home the same day. Each of my pre-surgical tests are pointing more and more in the wrong direction. After some research of my own, I decided to leave it. Historically, most patients with indeterminate thyroid nodule biopsies were referred for surgery though most would ultimately not have thyroid cancer (around 75% or more would have an unnecessary surgery). Largest is 2.3(previously 1.8cm in 2014) different test center though. Afirma Genomic Sequencing Classifier and Xpression Atlas - PubMed At least 1 genomic alteration was identified by the expanded Afirma XA panel in 70% of medullary thyroid carcinoma classifier-positive FNAs, 44% of Bethesda III or IV Afirma GSC suspicious FNAs, 64% of Bethesda V FNAs, and 87% of Bethesda VI FNAs. Comparison of Afirma GEC and GSC to Nodules Without Molecular Testing It's barely even hoarse. Wong KS et al. Bookshelf I am hesitant to go to surgery with the 30% cancer chance without more information. The Afirma GSC is a cancer rule-out test with a high negative predictive value so that cytologically indeterminate (Bethesda III/IV)2thyroid nodules with an Afirma GSC benign result can be considered for clinical observation in lieu of diagnostic surgical resection (Fig. I had three biopsies on a completely solid 2.0cm nodule, all which came back indeterminate/AUS. Thyroseq v3, Afirma GSC, and microRNA Panels Versus Previous Molecular Tests in the Preoperative Diagnosis of Indeterminate Thyroid Nodules: A Systematic Review and Meta-Analysis. That was a hard Thanksgiving.
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