Patients with a history of C. difficile infections should be closely monitored for recurrence, and the agent for prophylaxis should be carefully chosen. When planning a procedure or surgical intervention, one must consider the principles of infectious disease prophylaxis, which examine the questions: who, what, where, and when. 143,144, The most recent statement by the American Academy of Orthopedic Surgeons (AAOS) in February 2009 Antibiotic Prophylaxis for Bacteremia in Patients with Joint Replacements asserts that given the potential adverse outcomes and cost of treating an infected joint replacement, the AAOS recommends that clinicians consider antibiotic prophylaxis for all total joint replacement patients prior to any invasive procedure that may cause bacteremia., Surveillance systems for hospital-acquired infections do not record lower incident SSI, such as post-GU procedure associated periprosthetic joint infections, but rather are concerned with more common problems including CAUTI or infections with MDR organisms, as examples. Nunez-Nunez M, Navarro MD, Palomo V, et al: The methodology of surveillance for antimicrobial resistance and healthcare-associated infections in Europe (SUSPIRE): a systematic review of publicly available information. Urol Oncol 2016; 34: 256.e1. 62,63. Bakken JS, Borody T, Brandt LJ, et al: Treating clostridium difficile infection with fecal microbiota transplantation. In lower-risk Class II/clean-contaminated procedures such as office cystoscopy, AP does not provide a risk/benefit ratio supporting routine AP use. Current recommendations include first- and second-generation cephalosporins, or trimethoprim/sulfamethoxazole as a single dose. Prevention of clostridium difficile infection: a systematic survey of clinical practice guidelines. Van Hecke O, Wang K, Lee JJ, et al: The implications of antibiotic resistance for patients' recovery from common infections in the community: a systematic review and meta-analysis. 118. Particularly in the setting of implanted prosthetic devices, it is important to limit traffic in the operating room. Urology 2007; 69: 616. 69. Administration of prophylactic antibiotic within 1 hour before incision (2 hours for Vancomycin or Clindamycin) ABX 2. Pop-Vicas A, Musuuza JS, Schmitz M, et al: Incidence and risk factors for surgical site infection post-hysterectomy in a tertiary care center. Despite the availability of a comprehensive guideline outlining AP for general surgical procedures (revised in 2017) 1 and the American Urological Association (AUA) Best Practice Statement (BPS) Urologic Surgery Antimicrobial Prophylaxis (published in 2008 and reviewed in 2011), 2 tremendous variability in clinical practice persists, with known variation from hospital to hospital and provider to provider.
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